Miembros Académicos
Dr. Jorge González Cortes
Full Profesor of Parasitology
-B.S. in Medical Technology, Clinical Laboratory, University of Chile, 1980, Antofagasta, Chile.
-Doctor in Science. Department Microbiology, Parasitology and Immunology. Escola Paulista de Medicina (Universidade Federal Paulista), 1991. Sao Paulo, Brazil.
Dissertation: Surface antigens to 90 kDa and 35/50 kDa of metacyclic forms of Trypanosoma cruzi: possible function in protective immunity against acute infection and/or cellular invasion mechanisms. Graduate advisor: Dra Nobuko Yoshida
-Post Doctoral Training: Michael Heidelberger Division of Immunology, Pathology Department. New York University School of Medicine. December 1994-March 1998. Mentor: Dr. Victor Nussenzweig
Mi trabajo se orienta al estudio de los protozoos parásitos con énfasis en los estudios en Trypanosoma cruzi y Trichomonas vaginalis. Utilizando abordajes de proteómica y genómica, nos interesa conocer el papel de vías de señalización y de moléculas de superficie celular o excretadas secretadas en la virulencia y la interacción parásito-hospedador. Es también de nuestro interés la identificación de blancos quimioterapéuticos o inmunoprofilácticos. De igual manera, nos interesa desarrollar estudios de quimioterapia experimental de la enfermedad de Chagas, utilizando productos naturales aislados de plantas, algas o microalgas.
My work is oriented to the study of parasitic protozoa with emphasis on Trypanosoma cruzi and Trichomonas vaginalis. Using proteomics and genomics approaches, we are interested in understanding the role of signaling pathways and cell surface or excreted or secreted molecules in virulence and parasite-host interaction. We are also interested in the identification of chemotherapeutic or immunoprophylactic targets. Similarly, we are interested in developing experimental chemotherapy studies of Chagas disease, using natural products isolated from plants, algae or microalgae
1.-Torres V, Contreras V, Gutiérrez B, San Francisco J, Catalán A, Vega JL, Moon KM, Foster LJ, de Almeida RF, Kalergis AM, González J.(2024). Oral infectivity through carnivorism in murine model of Trypanosoma cruzi infection.
Front Cell Infect Microbiol. 2024 Feb 22;14:1297099. doi: 10.3389/fcimb.2024.1297099. eCollection 2024.
2.- Güiza J, Solís F, Valenzuela B, Arancibia D, Zamorano P, González J, Saavedra J, Neely A, Salgado M, Martínez AD, Sáez JC, Vega JL. (2023). Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms.Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2307898120. doi:10.1073/pnas.2307898120. Epub 2023 Jul 24.
3.- San Francisco J, Astudillo C, Vega JL, Catalán A, Gutiérrez B, Araya JE, Zailberger A, Marina A, García C, Sanchez N, Osuna A, Vilchez S, Ramírez MI, Macedo J, Feijoli VS, Palmisano G, González J. (2022). Trypanosoma cruzi pathogenicity involves virulence factor expression and upregulation of bioenergetic and biosynthetic pathways. Virulence.13(1):1827-1848. doi:10.1080/21505594.2022.2132776.
4.- Güiza J, García A, Arriagada J, Gutiérrez C, González J, Márquez-Miranda V, Alegría-Arcos M, Duarte Y, Rojas M, González-Nilo F, Sáez JC, Vega JL (2022). Unnexins: Homologs of innexin proteins in Trypanosomatidae parasites.J Cell Physiol. 237:1547-1560. doi: 10.1002/jcp.30626. Epub 2021 Nov 15.10.-15.
5.- Muñoz C, Pérez M, Orrego PR, Osorio L, Gutiérrez B, Sagua H, Castillo JL, Martínez-Oyanedel J, Arroyo R, Meza-Cervantez P, da Silveira JF, Midlej V, Benchimol M, Cordero E, Morales P, Araya JE, González J. 2012. A protein phosphatase 1 gamma (PP1γ) of the human protozoan parasite Trichomonas vaginalis is involved in proliferation and cell attachment to the host cell. Int J Parasitol. 42:715-727.
Contacto
Teléfono: (55) 2637376